Forschung
In Zusammenarbeit mit führenden Unternehmen der Pharmazie und Biotechnologie entwickelt Renishaw implantierbare Applikationssysteme zur Behandlung schwerer Erkrankungen des Zentralnervensystems (ZNS).
Verbesserung der präzisen Implantation von Therapien
Momentan arbeitet Renishaw mit führenden Unternehmen der Biotechnologie und Pharmazie zusammen, damit sich die im Labor Erfolg versprechenden Therapeutika auch applizieren lassen, wenn klinische Studien durchgeführt werden.
Die Komplexität dieses Schritts hat in der Vergangenheit dazu geführt, dass Therapieprogramme mit enormem Potenzial hinter den gesetzten Endpunkten zurückblieben.
In mehreren wichtigen Fällen ließen sich diese Fehlschläge zumindest teilweise darauf zurückführen, dass die Infusionslösung nicht auf einheitliche Weise präzise in das Zielvolumen appliziert und dort gehalten werden konnte.
Weitere Informationen
Momentan arbeitet Renishaw an der Entwicklung und Erprobung einer Reihe von Applikationssystemen der nächsten Generation, die wiederholbare Infusionsabläufe gewährleisten, was zu einer Stabilisierung hinsichtlich der beobachteten Wirksamkeit der Therapie sorgt.
Zusätzlich zum Angebot, dieses Entwicklungsportfolio in therapeutische und wissenschaftliche Forschungsprogramme zu integrieren, bietet Renishaw einen Beratungs- und Konstruktionsservice an, der Biotechnologie- und Pharmaunternehmen eine präzise Spezifikation der implantierbaren Applikationssysteme für eine optimale Applikation ihrer Therapeutika ermöglicht.
Verzeichnis der Artikel (peer-reviewed)
Die neurologischen Produkte von Renishaw wurden in zahlreichen Artikeln (peer-reviewed) erwähnt, wie z. B. den folgenden. In diesen Artikeln wird der wirksame Einsatz unserer Produkte im Bereich der funktionellen Neurochirurgie befürwortet.
Produkt | Anwendung | Autoren | Jahr | Titel | DOI-Link |
| neurolocate™ rahmenloses Registriermodul | SEEG | Cardinale, F. et al | 2017 | A new tool for touch-free patient registration for robotic-assisted intercranial surgery: application accuracy from a phantom study and a retrospective surgical series | DOI |
| neuroinspire™-Software | DBS | Geevarghese, R. et al | 2016 | Registration accuracy of CT/MRI fusion for localisation of deep brain stimulation electrode position: an imaging study and systematic review | DOI |
| Applikation von Medikamenten | Applikation von Medikamenten | Barua, N.U. et al | 2016 | A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Kajita, Y. et al | 2015 | Installation of a neuromate robot for stereotactic surgery: efforts to conform to Japanese specifications and an approach for clinical use | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | von Langsdorf, D. et al | 2015 | In vivo measurement of the frame-based application accuracy of the neuromate neurosurgical robot | DOI |
| Stereotaktischer Roboter neuromate ® | Porfirio, B. et al | 2015 | Donor-specific anti-HLA antibodies in Huntington's disease recipients of human fetal striatal grafts | DOI | |
| Stereotaktischer Roboter neuromate ® | SEEG | Cardinale, F. | 2015 | Stereotactic robotic application accuracy is very high in 'in vivo' procedures | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Paganini, M. et al | 2013 | Fetal striatal grafting slows motor and cognitive decline of Huntington's disease | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Abhinav, K. et al | 2013 | Use of robot-guided stereotactic placement of intracerebral electrodes for investigation of focal epilepsy: initial experience in the UK | DOI |
Stereotaktischer Roboter neuromate ® | Applikation von Medikamenten | Barua, N.U. et al | 2013 | Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma. Acta Neurochirurgica | |
| Stereotaktischer Roboter neuromate ® | SEEG | Cardinale, F. et al | 2013 | Stereoelectroencephalography: Surgical Methodology, Safety, and Stereotactic Application Accuracy in 500 Procedures. Neurosurgery, 72(3):353-366 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Sieradzan, K. et al | 2013 | Robotic stereo EEG in epilepsy surgery assessment, Journal of Neurology, Neurosurgery and Psychiatry, 84(e2):46 | DOI |
| Stereotaktischer Roboter neuromate ® | Biopsie | Dellaretti, M. et al | 2012 | Stereotactic Biopsy for Brainstem Tumors: Comparison of Transcerebellar with Transfrontal Approach, Stereotactic and Functional Neurosurgery, 90:79-83 | DOI |
| Stereotaktischer Roboter neuromate ® | Biopsie | Dellaretti, M. et al | 2012 | Correlation between magnetic resonance imaging findings and histological diagnosis of intrinsic brainstem lesions in adults, Neuro-Oncology, 14(3):381-385 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2012 | Stereoelectroencephalography in the presurgical evaluation of focal epilepsy in infancy and early childhood. Journal of Neurosurgery: Pediatrics, 9(3):290-300 | DOI |
| neuroguide ® - Implantationssystem für DBS-Elektroden | DBS | Khan, S. et al | 2010 | A magnetic resonance imaging-directed method for transventricular targeting of midline structures for deep brain stimulation using implantable guide tubes. Neurosurgery, 66(6 Suppl Operative):234-7 | DOI |
| Stereotaktischer Roboter neuromate ® | Biopsie | Haegelen, C. et al | 2010 | Stereotactic robot-guided biopsies of brain stem lesions: Experience with 15 cases. | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Gallina, P. et al | 2010 | Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation. Experimental neurology, 222(1):30-41 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Afif, A. et al | 2010 | Anatomofunctional organization of the insular cortex: A study using intracerebral electrical stimulation in epileptic patients. Epilepsia, 51(11):2305-15 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Afif, A. et al | 2010 | Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy. Epilepsia, 51(2):206-13 | DOI |
| neuroguide ® - Implantationssystem für DBS-Elektroden | DBS | Khan, S. et al | 2009 | High frequency stimulation of the mamillothalamic tract for the treatment of resistant seizures associated with hypothalamic hamartoma. Epilepsia, 50(6):1608-11 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Narayana, S. et al | 2009 | A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease. American journal of speech-language pathology, 18(2):146-61 | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Gallina, P. et al | 2008 | Development of human striatal anlagen after transplantation in a patient with Huntington's disease. Experimental neurology, 213(1):241-4 | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Gallina, P. et al | 2008 | Human fetal striatal transplantation in Huntington's disease: a refinement of the stereotactic procedure. Stereotactic and functional neurosurgery, 86(5):308-13 | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Paganini, M. et al | 2008 | Fetal striatal grafting slows motor and cognitive decline of Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry | DOI |
| Stereotaktischer Roboter neuromate ® | Zelltransplantation | Derrey, S. et al | 2008 | Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation. Neurosurgery, 63(6):1045-52 | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Breit, S. et al | 2008 | Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography. Neurosurgery, 62(2 Suppl):840-52 | DOI |
| Stereotaktischer Roboter neuromate ® | Endoskopie | Dorfmüller, G. et al | 2008 | [Surgical disconnection of hypothalamic hamartomas]. Neuro- Chirurgie, 54(3):315-9 | DOI |
| Stereotaktischer Roboter neuromate ® | Allgemein | Xia, T. et al | 2008 | An integrated system for planning, navigation and robotic assistance for skull base surgery. The international journal of medical robotics + computer assisted surgery, 4(4):321-3 0 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Afif, A. et al | 2008 | Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery, 62(5 Suppl 2):ONS471-9 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Afif, A. et al | 2008 | Middle short gyrus of the insula implicated in pain processing. Pain, 138(3):546-55 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2008 | [Presurgical evaluation of intractable epilepsy using stereo- electro-encephalography methodology: principles, technique and morbidity]. Neuro-Chirurgie, 54(3):367-73 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Bulteau, C. et al | 2008 | [Epilepsy surgery during infancy and early childhood in France]. Neuro-Chirurgie, 54(3):342-6 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2008 | Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia, 49(1):65-72 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Laird, A. et al | 2008 | Modeling motor connectivity using TMS/PET and structural equation modeling. NeuroImage, 41(2):424-36 | DOI |
| neuroguide ® - Implantationssystem für DBS-Elektroden | DBS | Patel, N.K. et al | 2007 | Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes. Neurosurgery, 61(5 Suppl 2):358-65 | DOI |
| Stereotaktischer Roboter neuromate ® | Endoskopie | Procaccini, E. et al | 2006 | Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery, 59(4 Suppl 2): ONS336-44 | DOI |
| Stereotaktischer Roboter neuromate ® | Allgemein | Varma, T. et al | 2006 | Use of the NeuroMate stereotactic robot in a frameless mode for functional neurosurgery. The international journal of medical robotics + computer assisted surgery,2(2):107-13 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2006 | Stereo-EEG in children. Child's nervous system, 22(8):766- 78 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Fox, P. et al | 2006 | Intensity modulation of TMS-induced cortical excitation: primary motor cortex. Human brain mapping, 27(6):478-87 | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Haegelen, C. et al | 2005 | Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method. Surgical and radiologic anatomy, 27(5):389-94 | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Sauleau, P. et al | 2005 | Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson's disease. Journal of neurology, 252(4):457-64 | DOI |
| Stereotaktischer Roboter neuromate ® | Allgemein | Rossi, A. et al | 2005 | A telerobotic haptic system for minimally invasive stereotactic neurosurgery. The international journal of medical robotics + computer assisted surgery, 1(2):64-75 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2005 | Stereoelectroencephalography in the presurgical evaluation of children with drug-resistant focal epilepsy. Journal of neurosurgery, 103(4 Suppl): 333-43 | DOI |
| Stereotaktischer Roboter neuromate ® | SEEG | Cossu, M. et al | 2005 | Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures. Neurosurgery, 57(4):706-18 | DOI |
| Stereotaktischer Roboter neuromate ® | Allgemein | Zamorano, L. et al | 2004 | Robotics in neurosurgery: state of the art and future technological challenges. The international journal of medical robotics + computer assisted surgery, 1(1):7-22 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Fox, P. et al | 2004 | Column-based model of electric field excitation of cerebral cortex. Human brain mapping, 22(1):1-14 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Lancaster, J. L. et al | 2004 | Evaluation of an image-guided, robotically positioned transcranial magnetic stimulation system. Human brain mapping, 22(4):329-40 | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Varma, T. et al | 2003 | Use of the NeuroMate stereotactic robot in a frameless mode for movement disorder surgery. Stereotactic and functional neurosurgery, 80(1-4):132-5 | DOI |
| Stereotaktischer Roboter neuromate ® | DBS | Littlechild, P. et al | 2003 | Variability in position of the subthalamic nucleus targeted by magnetic resonance imaging and microelectrode recordings as compared to atlas co-ordinates. Stereotactic and functional neurosurgery, 80(1-4):82-7 | DOI |
| Stereotaktischer Roboter neuromate ® | Transkranielle Magnetstimulation | Lee, J. S. et al | 2003 | Positron emission tomography during transcranial magnetic stimulation does not require μ-metal shielding, NeuroImage, 19(4):1812-9 | DOI |
| Stereotaktischer Roboter neuromate ® | Allgemein | Li, Q. et al | 2002 | The application accuracy of the NeuroMate robot ⬜ A quantitative comparison with frameless and frame-based surgical localization systems. Computer aided surgery, 7(2):90-8 | DOI |
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