Research
In collaboration with leading pharmaceutical and biotechnology companies, Renishaw is working on developing implantable therapeutic delivery devices for the treatment of serious Central Nervous System (CNS) diseases.
Advancing precision delivery of therapeutics
Renishaw is currently working with leading biotechnology and pharmaceutical companies to ensure that therapeutics that are showing great promise in the laboratory, have a means of delivery when clinical trials are performed.
The complexities of taking this step have historically led to therapy programmes with great potential failing to hit designated end-points.
In several key cases these failures can at least be partly attributed to an inability to be consistent in the precise delivery and containment of the infusate in targeted volumes.
Further information
Renishaw is currently developing and testing a range of next-generation delivery devices that are demonstrating repeatability in infusion patterns, leading to consistency in observed therapy efficacy.
In addition to offering to incorporate this development portfolio into therapeutic and academic research programmes, Renishaw offers a consultancy and associated design service to allow biotechnology and pharmaceutical companies to precisely specify delivery systems for optimal delivery of their therapeutics.
Peer-reviewed library
Renishaw's neurological products have featured in many peer-reviewed publications, including those below. These articles support the effective use of our products in functional neurosurgery.
Product | Application | Authors | Year | Title | DOI link |
| neurolocate™ frameless registration module | SEEG | Cardinale, F. et al | 2017 | A new tool for touch-free patient registration for robotic-assisted intercranial surgery: application accuracy from a phantom study and a retrospective surgical series | DOI |
| neuroinspire™ software | DBS | Geevarghese, R. et al | 2016 | Registration accuracy of CT/MRI fusion for localisation of deep brain stimulation electrode position: an imaging study and systematic review | DOI |
| Drug delivery | Drug delivery | Barua, N.U. et al | 2016 | A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma | DOI |
| neuromate ® stereotactic robot | DBS | Kajita, Y. et al | 2015 | Installation of a neuromate robot for stereotactic surgery: efforts to conform to Japanese specifications and an approach for clinical use | DOI |
| neuromate ® stereotactic robot | DBS | von Langsdorf, D. et al | 2015 | In vivo measurement of the frame-based application accuracy of the neuromate neurosurgical robot | DOI |
| neuromate ® stereotactic robot | Porfirio, B. et al | 2015 | Donor-specific anti-HLA antibodies in Huntington's disease recipients of human fetal striatal grafts | DOI | |
| neuromate ® stereotactic robot | SEEG | Cardinale, F. | 2015 | Stereotactic robotic application accuracy is very high in 'in vivo' procedures | DOI |
| neuromate ® stereotactic robot | Cell graft | Paganini, M. et al | 2013 | Fetal striatal grafting slows motor and cognitive decline of Huntington's disease | DOI |
| neuromate ® stereotactic robot | SEEG | Abhinav, K. et al | 2013 | Use of robot-guided stereotactic placement of intracerebral electrodes for investigation of focal epilepsy: initial experience in the UK | DOI |
neuromate ® stereotactic robot | Drug delivery | Barua, N.U. et al | 2013 | Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma. Acta Neurochirurgica | |
| neuromate ® stereotactic robot | SEEG | Cardinale, F. et al | 2013 | Stereoelectroencephalography: Surgical Methodology, Safety, and Stereotactic Application Accuracy in 500 Procedures. Neurosurgery, 72(3):353-366 | DOI |
| neuromate ® stereotactic robot | SEEG | Sieradzan, K. et al | 2013 | Robotic stereo EEG in epilepsy surgery assessment, Journal of Neurology, Neurosurgery and Psychiatry, 84(e2):46 | DOI |
| neuromate ® stereotactic robot | Biopsy | Dellaretti, M. et al | 2012 | Stereotactic Biopsy for Brainstem Tumors: Comparison of Transcerebellar with Transfrontal Approach, Stereotactic and Functional Neurosurgery, 90:79-83 | DOI |
| neuromate ® stereotactic robot | Biopsy | Dellaretti, M. et al | 2012 | Correlation between magnetic resonance imaging findings and histological diagnosis of intrinsic brainstem lesions in adults, Neuro-Oncology, 14(3):381-385 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2012 | Stereoelectroencephalography in the presurgical evaluation of focal epilepsy in infancy and early childhood. Journal of Neurosurgery: Pediatrics, 9(3):290-300 | DOI |
| neuroguide ® - DBS electrode delivery system | DBS | Khan, S. et al | 2010 | A magnetic resonance imaging-directed method for transventricular targeting of midline structures for deep brain stimulation using implantable guide tubes. Neurosurgery, 66(6 Suppl Operative):234-7 | DOI |
| neuromate ® stereotactic robot | Biopsy | Haegelen, C. et al | 2010 | Stereotactic robot-guided biopsies of brain stem lesions: Experience with 15 cases. | DOI |
| neuromate ® stereotactic robot | Cell graft | Gallina, P. et al | 2010 | Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation. Experimental neurology, 222(1):30-41 | DOI |
| neuromate ® stereotactic robot | SEEG | Afif, A. et al | 2010 | Anatomofunctional organization of the insular cortex: A study using intracerebral electrical stimulation in epileptic patients. Epilepsia, 51(11):2305-15 | DOI |
| neuromate ® stereotactic robot | SEEG | Afif, A. et al | 2010 | Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy. Epilepsia, 51(2):206-13 | DOI |
| neuroguide ® - DBS electrode delivery system | DBS | Khan, S. et al | 2009 | High frequency stimulation of the mamillothalamic tract for the treatment of resistant seizures associated with hypothalamic hamartoma. Epilepsia, 50(6):1608-11 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Narayana, S. et al | 2009 | A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease. American journal of speech-language pathology, 18(2):146-61 | DOI |
| neuromate ® stereotactic robot | Cell graft | Gallina, P. et al | 2008 | Development of human striatal anlagen after transplantation in a patient with Huntington's disease. Experimental neurology, 213(1):241-4 | DOI |
| neuromate ® stereotactic robot | Cell graft | Gallina, P. et al | 2008 | Human fetal striatal transplantation in Huntington's disease: a refinement of the stereotactic procedure. Stereotactic and functional neurosurgery, 86(5):308-13 | DOI |
| neuromate ® stereotactic robot | Cell graft | Paganini, M. et al | 2008 | Fetal striatal grafting slows motor and cognitive decline of Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry | DOI |
| neuromate ® stereotactic robot | Cell graft | Derrey, S. et al | 2008 | Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation. Neurosurgery, 63(6):1045-52 | DOI |
| neuromate ® stereotactic robot | DBS | Breit, S. et al | 2008 | Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography. Neurosurgery, 62(2 Suppl):840-52 | DOI |
| neuromate ® stereotactic robot | Endoscopy | Dorfmüller, G. et al | 2008 | [Surgical disconnection of hypothalamic hamartomas]. Neuro- Chirurgie, 54(3):315-9 | DOI |
| neuromate ® stereotactic robot | General | Xia, T. et al | 2008 | An integrated system for planning, navigation and robotic assistance for skull base surgery. The international journal of medical robotics + computer assisted surgery, 4(4):321-3 0 | DOI |
| neuromate ® stereotactic robot | SEEG | Afif, A. et al | 2008 | Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery, 62(5 Suppl 2):ONS471-9 | DOI |
| neuromate ® stereotactic robot | SEEG | Afif, A. et al | 2008 | Middle short gyrus of the insula implicated in pain processing. Pain, 138(3):546-55 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2008 | [Presurgical evaluation of intractable epilepsy using stereo- electro-encephalography methodology: principles, technique and morbidity]. Neuro-Chirurgie, 54(3):367-73 | DOI |
| neuromate ® stereotactic robot | SEEG | Bulteau, C. et al | 2008 | [Epilepsy surgery during infancy and early childhood in France]. Neuro-Chirurgie, 54(3):342-6 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2008 | Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia, 49(1):65-72 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Laird, A. et al | 2008 | Modeling motor connectivity using TMS/PET and structural equation modeling. NeuroImage, 41(2):424-36 | DOI |
| neuroguide ® - DBS electrode delivery system | DBS | Patel, N.K. et al | 2007 | Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes. Neurosurgery, 61(5 Suppl 2):358-65 | DOI |
| neuromate ® stereotactic robot | Endoscopy | Procaccini, E. et al | 2006 | Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery, 59(4 Suppl 2): ONS336-44 | DOI |
| neuromate ® stereotactic robot | General | Varma, T. et al | 2006 | Use of the NeuroMate stereotactic robot in a frameless mode for functional neurosurgery. The international journal of medical robotics + computer assisted surgery,2(2):107-13 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2006 | Stereo-EEG in children. Child's nervous system, 22(8):766- 78 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Fox, P. et al | 2006 | Intensity modulation of TMS-induced cortical excitation: primary motor cortex. Human brain mapping, 27(6):478-87 | DOI |
| neuromate ® stereotactic robot | DBS | Haegelen, C. et al | 2005 | Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method. Surgical and radiologic anatomy, 27(5):389-94 | DOI |
| neuromate ® stereotactic robot | DBS | Sauleau, P. et al | 2005 | Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson's disease. Journal of neurology, 252(4):457-64 | DOI |
| neuromate ® stereotactic robot | General | Rossi, A. et al | 2005 | A telerobotic haptic system for minimally invasive stereotactic neurosurgery. The international journal of medical robotics + computer assisted surgery, 1(2):64-75 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2005 | Stereoelectroencephalography in the presurgical evaluation of children with drug-resistant focal epilepsy. Journal of neurosurgery, 103(4 Suppl): 333-43 | DOI |
| neuromate ® stereotactic robot | SEEG | Cossu, M. et al | 2005 | Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures. Neurosurgery, 57(4):706-18 | DOI |
| neuromate ® stereotactic robot | General | Zamorano, L. et al | 2004 | Robotics in neurosurgery: state of the art and future technological challenges. The international journal of medical robotics + computer assisted surgery, 1(1):7-22 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Fox, P. et al | 2004 | Column-based model of electric field excitation of cerebral cortex. Human brain mapping, 22(1):1-14 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Lancaster, J. L. et al | 2004 | Evaluation of an image-guided, robotically positioned transcranial magnetic stimulation system. Human brain mapping, 22(4):329-40 | DOI |
| neuromate ® stereotactic robot | DBS | Varma, T. et al | 2003 | Use of the NeuroMate stereotactic robot in a frameless mode for movement disorder surgery. Stereotactic and functional neurosurgery, 80(1-4):132-5 | DOI |
| neuromate ® stereotactic robot | DBS | Littlechild, P. et al | 2003 | Variability in position of the subthalamic nucleus targeted by magnetic resonance imaging and microelectrode recordings as compared to atlas co-ordinates. Stereotactic and functional neurosurgery, 80(1-4):82-7 | DOI |
| neuromate ® stereotactic robot | Transcranial magnetic stimulation | Lee, J. S. et al | 2003 | Positron emission tomography during transcranial magnetic stimulation does not require μ-metal shielding, NeuroImage, 19(4):1812-9 | DOI |
| neuromate ® stereotactic robot | General | Li, Q. et al | 2002 | The application accuracy of the NeuroMate robot ⬜ A quantitative comparison with frameless and frame-based surgical localization systems. Computer aided surgery, 7(2):90-8 | DOI |
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